CRP Full Form | What Does CRP Stand For?

CRP: C-Reactive Protein

CRP Full Form

CRP full form stands for C-Reactive Protein. C-reactive protein (CRP) is a condenser (color-shaped), a pentameric protein found in blood plasma, whose circulating concentration increases in response to inflammation.

It is an acute-phase protein of liver origin that is increased by macrophages and T cells after interleukin 6 secretion.

Brief History

  • After being discovered by Tillett and Francis in 1930, it was initially thought that CRP may lead to pathogenic secretions due to a number of diseases, including cancer.
  • Later discovery of liver synthesis showed that it is a local protein. Initially, CRP was measured using a cloning reaction that produced positive or negative results. Nowadays, more precise methods use dynamic light scattering after reacting with CRP-specific antibodies.

Functions

  • It plays a role in natural immunity as an initial immunity against infection.
  • Its physiological role is to bind to lysophosphatidylcholine, which appears on the surface of dead or dying cells to activate the complement system via C1Q.
  • CRP is associated with phosphocholine stimulates the complement system to promote phagocytosis by macrophages, which cleaves neurotic and apoptotic cells and bacteria.
  • This so-called acute-phase reaction arises from an increased concentration of IL-6. These conditions cause the release of interleukin 6 and other cytokines that stimulate the synthesis of CRP and fibrinogen by the liver.
  • CRP binds phosphocholine to microorganisms. This helps in the extra-ligation of foreign and damaged cells and may enhance phagocytosis via macrophages.

What Is The Full Form Of CRP?

CRP full form stands for C-Reactive Protein. It is a condenser (color-shaped), a pentameric protein found in blood plasma, whose circulating concentration increases in response to inflammation. It plays a role in natural immunity as an initial immunity against infection.

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